The way to fill out a MulOptimal matrix with the right data is to first write the data in row/column layout and then do a matrix conversion to optimal layout. Keep in mind that you need to query the destination size on the CPU before you allocate memory for the optimal layout matrix using ID3D12Device::GetLinearAlgebraMatrixConversionDestinationInfo. This is because the size is implementation-dependent (vendor, driver, etc.) and might require more memory than you would expect. Once this is queried and the data allocated, we can perform the conversion using ID3D12GraphicsCommandList::ConvertLinearAlgebraMatrix.
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