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The idea is very simple: for any sequence, replace a repeated run of any nucleotide (i.e. homopolymers) by a single occurrence of that nucleotide. This means that after going through HPC the sequence AAACTGGG will yield the sequence ACTG. This simple pre-processing step, applied to all the reads and sequences to analyze, removes all indels in homopolymers, and can resolve some ambiguities (c.f. Figure 1.6). It can also remove legitimate information contained in homopolymers, but the trade-off with the reduced error rate has been deemed advantageous.
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the tasks that ERMA was taking over. Since the 1930s, IBM had produced a line of
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待播剧《我的山与海》《芳名三九》同样聚焦女性的自我觉醒与奋斗精神。《我的山与海》中，女主方婉之从“县长千金”跌落为“大山弃婴”，面对身份崩塌、社会偏见与生存困境，从流水线女工做起，边打工边读夜大、学英语，在底层摸爬滚打中积累力量。
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